SODIUM NITROPRUSSIDE AND LIBERATION OF CYANIDE
نویسندگان
چکیده
منابع مشابه
Cyanide and thiocyanate concentrations following sodium nitroprusside infusion in man.
Twenty-six patients, receiving an infusion of sodium nitroprusside (SNP) during surgery, had considerable increases in both red cell and plasma cyanide concentration, but only small changes in plasma thiocyanate concentration. There was a linear relationship between both plasma and RBC cyanide concentrations and the total dose of SNP. The expired cyanide concentration followed the changes in th...
متن کاملNitroprusside and cyanide.
Sir,—An otherwise excellent and thorough report by Vesey, Cole and Simpson (1976) fails to acknowledge or refute a hypothesis which has already appeared in this Journal (Smith and Kruszyna, 1976a) about the mechanism by which cyanide is released from nitroprusside in vivo, and the significance of that reaction for blood cyanide concentrations. We are delighted with the confirmation that "The re...
متن کاملIn vivo release of cyanide from sodium nitroprusside.
Brain cytochrome oxidase activity was measured after the in vitro addition of potassium cyanide (KCN) or sodium nitroprusside (SNP). Activity of cytochrome oxidase was sensitive to KCN; however, this activity was unaffected by SNP. In SNP- and KCN-treated animals brain cytochrome oxidase activities were measured. At 3 min after SNP injection, inhibition of the enzymatic activity was the same as...
متن کاملSome physiological and metabolic effects of sodium nitroprusside and cyanide in the dog.
The cardiovascular and acid-base changes following equivalent i.v. bolus doses of sodium nitroprusside (SNP) and potassium cyanide (KCN) have been studied in two groups of anaesthetized dogs. In a third group, the metabolic changes produced by i.v. infusion of SNP 1.5 mg kg-1 at a constant rate over 1 h have been studied. In contrast to a decrease in arterial pressure following SNP, hypertensio...
متن کاملBlood cyanide and thiocyanate concentrations produced by long-term therapy with sodium nitroprusside.
Blood cyanide (HCN) or plasma thiocyanate (SCN) concentrations, or both, were measured in 30 patients (ages 11 months-72 yr) receiving sodium nitroprusside (SNP) for 12-314 h. Sequential measurements in three of these patients (infused 5, 12 and 13 days) showed that HCN concentrations varied with dose rate, while SCN concentrations increased linearly with increasing SNP dose. The accumulated da...
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ژورنال
عنوان ژورنال: British Journal of Anaesthesia
سال: 1978
ISSN: 0007-0912
DOI: 10.1093/bja/50.11.1169-a